8.52288
Fmoc-Phe(CF2PO3)-OH
≥90.0% (HPLC), for peptide synthesis, Novabiochem®
别名:
Fmoc-Phe(CF2PO3)-OH, Fmoc-F 2Pmp-OH,Fmoc-L-p-(phosphono-difluoromethyl)phenylalanine
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关于此项目
经验公式（希尔记法）:
C25H22F2NO7P
化学文摘社编号:
分子量:
517.42
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
产品名称
Fmoc-Phe(CF2PO3)-OH, Novabiochem®
SMILES string
FC(F)([P](=O)(O)O)c1ccc(cc1)C[C@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)C(=O)O
InChI
1S/C25H22F2NO7P/c26-25(27,36(32,33)34)16-11-9-15(10-12-16)13-22(23(29)30)28-24(31)35-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,28,31)(H,29,30)(H2,32,33,34)/t22-/m0/s1
InChI key
XKWYQNFAGUNPJV-QFIPXVFZSA-N
product line
Novabiochem®
assay
≥90.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
Quality Level
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 90.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %
General description
Building block [1] for the introduction by Fmoc SPPS of the hydrolytically stable phosphotyrosine analog phosphonodifluoromethylphenylalanine (F2Pmp) [2]. The pKa of F2Pmp more closely resembles that of a phosphate group making it better analog than phosphonomethylphenylalanine.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS
Literature references
[1] M. F. Gordeev, et al. (1994) Tetrahedron Lett., 35, 7585.
[2] T. R. Burke, Jr. (2006) Curr. Top. Med. Chem., 6, 1465.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS
Literature references
[1] M. F. Gordeev, et al. (1994) Tetrahedron Lett., 35, 7585.
[2] T. R. Burke, Jr. (2006) Curr. Top. Med. Chem., 6, 1465.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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