推荐产品
产品名称
Fmoc-Gly-(Dmb)Gly-OH, Novabiochem®
质量水平
产品线
Novabiochem®
方案
≥90.0% (acidimetric)
≥95.0% (HPLC)
≥98% (TLC)
表单
powder
反应适用性
reaction type: Fmoc solid-phase peptide synthesis
制造商/商品名称
Novabiochem®
应用
peptide synthesis
官能团
Fmoc
储存温度
2-8°C
SMILES字符串
N(Cc4c(cc(cc4)OC)OC)(CC(=O)O)C(=O)CNC(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C28H28N2O7/c1-35-19-12-11-18(25(13-19)36-2)15-30(16-27(32)33)26(31)14-29-28(34)37-17-24-22-9-5-3-7-20(22)21-8-4-6-10-23(21)24/h3-13,24H,14-17H2,1-2H3,(H,29,34)(H,32,33)
InChI key
NJUCBQMDTSVIGD-UHFFFAOYSA-N
一般描述
The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin [1]. Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS
Literature references
[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS
Literature references
[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.
联系
Replaces: 04-12-1266
分析说明
Color (visual): white to slight yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
实验方案
The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis.
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