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质量水平
产品线
Novabiochem®
表单
solid
反应适用性
reaction type: Fmoc solid-phase peptide synthesis
制造商/商品名称
Novabiochem®
应用
peptide synthesis
官能团
carboxylic acid
储存温度
15-25°C
SMILES字符串
N([C@@H](CC(=O)OC(CC)(CC)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C25H29NO6/c1-4-25(3,5-2)32-22(27)14-21(23(28)29)26-24(30)31-15-20-18-12-8-6-10-16(18)17-11-7-9-13-19(17)20/h6-13,20-21H,4-5,14-15H2,1-3H3,(H,26,30)(H,28,29)/t21-/m0/s1
InChI key
SYGKUYKLHYQKPL-NRFANRHFSA-N
一般描述
An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides [1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group [1,2].
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
[2] M. Mergler (2003) J. Pept. Sci., 9, 518.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] A. Karlström (1996) Tetrahedron Lett., 37, 4243.
[2] M. Mergler (2003) J. Pept. Sci., 9, 518.
联系
Replaces: 04-12-1259
分析说明
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
商品
Aspartimide formation 1,2 is caused by repeated exposure of aspartic acid-containing sequences to bases like piperidine and can result ultimately in the generation of 9 different by-products.
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