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Merck
CN

8.52095

Fmoc-Lys(Mca)-OH

≥97.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

Fmoc-Lys(Mca)-OH, N-α-Fmoc-N-ε-7-methoxycoumarin-4-acetyl-L-lysine

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关于此项目

经验公式（希尔记法）:
C33H32N2O8
化学文摘社编号:
386213-32-7
分子量:
584.62
MDL number:
MFCD03791024
UNSPSC Code:
12352209
NACRES:
NA.22

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产品名称

Fmoc-Lys(Mca)-OH, Novabiochem®

SMILES string

N([C@@H](CCCCNC(=O)Cc4c5c([o][c](c4)=O)cc(cc5)OC)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C33H32N2O8/c1-41-21-13-14-22-20(17-31(37)43-29(22)18-21)16-30(36)34-15-7-6-12-28(32(38)39)35-33(40)42-19-27-25-10-4-2-8-23(25)24-9-3-5-11-26(24)27/h2-5,8-11,13-14,17-18,27-28H,6-7,12,15-16,19H2,1H3,(H,34,36)(H,35,40)(H,38,39)/t28-/m0/s1

InChI key

BWJJONDPLYEAMC-NDEPHWFRSA-N

product line

Novabiochem®

assay

≥97% (TLC)
≥97.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

−20°C

Quality Level

200

相关类别

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

General description

A modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc SPPS [1]. The Mca group fluoresces at 405 nm when stimulated at 340 nm, and is most commonly used in conjunction with Dabcyl and 2,4-dinitrophenyl quenching groups. Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation [2]. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Chromogenic Labeling of Synthetic Peptides

Literature references

[1] J. L. Lauer-Fields, et al. (2001) Biochemistry, 40, 5795.
[2] C. F. W. Becker, et al. (2004) Bioconjugate Chem., 15, 1118.

Other Notes

Replaces: 04-12-1233

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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