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Merck
CN
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文件

8.52066-M

Sigma-Aldrich

Fmoc-Thr(Trt)-OH

Novabiochem®

别名:

Fmoc-Thr(Trt)-OH, N-α-Fmoc-O-trityl-L-threonine

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About This Item

经验公式(希尔记法):
C38H33NO5
分子量:
583.67
UNSPSC代码:
12352209
NACRES:
NA.22

质量水平

检测方案

≥78.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)

形式

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

mp

70-85 °C

应用

peptide synthesis

官能团

hydroxyl

储存温度

15-25°C

InChI

1S/C38H33NO5/c1-26(44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29)35(36(40)41)39-37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34/h2-24,26,34-35H,25H2,1H3,(H,39,42)(H,40,41)/t26-,35+/m1/s1

InChI key

JARBLLDDSTVWSM-IJAHGLKVSA-N

一般描述

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

联系

Replaces: 04-12-1141

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 78.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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商品

Novabiochem® offers orthogonally protected amino acids for peptide synthesis, including cyclic and branched peptides.

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