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8.52011

Sigma-Aldrich

Fmoc-Leu-OH

Novabiochem®

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别名:
Fmoc-Leu-OH, N-α-Fmoc-L-leucine
经验公式(希尔记法):
C21H23NO4
CAS号:
分子量:
353.41
MDL编号:
UNSPSC代码:
12352209
EC索引号:
252-662-7
NACRES:
NA.22

质量水平

产品线

Novabiochem®

检测方案

≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)

形式

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

mp

145-153 °C

应用

peptide synthesis

官能团

Fmoc

储存温度

2-30°C

InChI

1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)

InChI key

CBPJQFCAFFNICX-UHFFFAOYSA-N

一般描述

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of leucine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

应用

  • Fmoc-protection efficiency: Addressing the efficiency and recrystallization needs in the Fmoc-protection process (R Yoshino et al., 2017).
  • Isotopic labeling for NMR: Development of 17O isotopic labeling of N-Formyl-MLF-OH and related building blocks, enhancing NMR spectroscopy applications (M Ha et al., 2021).
  • Perovskite solar cell modification: Investigating the role of Fmoc-Leu-OH in modifying perovskite film to enhance solar cell efficiency (J Song et al., 2022).

联系

Replaces: 04-12-1025

分析说明

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.8 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Leu-Leu-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Ile-OH (GC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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Yun Song et al.
Cell reports, 30(8), 2699-2711 (2020-02-27)
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1 and HDAC1, held together by the

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