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8.52000

Sigma-Aldrich

Fmoc-Thr(tBu)-OH

Novabiochem®

别名:

Fmoc-Thr(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-threonine

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About This Item

经验公式（希尔记法）:
C23H27NO5
CAS号:
71989-35-0
分子量:
397.46
MDL编号:
MFCD00077075
UNSPSC代码:
12352209
EC索引号:
276-261-1
NACRES:
NA.22

质量水平

400

产品线

Novabiochem®

方案

≥98% (TLC)
≥98.0% (acidimetric)
≥99.0% (HPLC)

表单

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

mp

125-135 °C

应用

peptide synthesis

官能团

hydroxyl

储存温度

2-30°C

SMILES字符串

N([C@@H]([C@H](OC(C)(C)C)C)C(=O)[O-])C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/p-1/t14-,20+/m1/s1

InChI key

LZOLWEQBVPVDPR-VLIAUNLRSA-M

相关类别

一般描述

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
Standard building block for introduction of threonine amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

应用


  • Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group: This study demonstrates the effective use of Fmoc-Thr(tBu)-OH in the synthesis of N-methyl amino acids, which are crucial in developing peptidomimetic drugs (Román et al., 2023).

  • Controlled Morphological Changes in Self-Assembled Structures Formed by Fmoc Variants of Threonine and Serine: Explores how Fmoc-Thr(tBu)-OH influences the self-assembly and structural morphology of peptidic materials, relevant in material science (Kshtriya et al., 2021).

  • Solid-phase Synthesis of C-terminus Cysteine Peptide Acids: This article includes the use of Fmoc-Thr(tBu)-OH in the synthesis of peptides containing cysteine, which are significant in both drug design and biochemical studies (Mthembu et al., 2022).

  • Polymer-Supported Stereoselective Synthesis of Benzoxazinothiadiazepinone 6,6-dioxides: Discusses the use of Fmoc-Thr(tBu)-OH in the stereoselective synthesis of novel organic compounds with potential applications in medicinal chemistry (Králová et al., 2017).


联系

Replaces: 04-12-1000

分析说明

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.7 % (a/a)
Purity (HPLC): ≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-ß-Ala-Thr(tBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Thr(tBu)-Thr(tBu)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Thr-OH (HPLC): ≤ 0.1 % (a/a)
Assay free amino acid (GC): ≤ 0.2 %
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (25 mmole in 50 ml DMF): clearly soluble
Assay (acidimetric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.02 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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