推荐产品
产品名称
PyAOP, Novabiochem®
质量水平
产品线
Novabiochem®
表单
powder
反应适用性
reaction type: Coupling Reactions
制造商/商品名称
Novabiochem®
应用
peptide synthesis
储存温度
15-25°C
SMILES字符串
F[P-](F)(F)(F)(F)F.[P](=[N+]5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1nccc2
InChI
1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
InChI key
CBZAHNDHLWAZQC-UHFFFAOYSA-N
一般描述
PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references:
[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references:
[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.
应用
PyAOP can be used as a coupling reagent:
- In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
- To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.
分析说明
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Solid-phase synthesis of N, N?-substituted acylguanidines
Dodd DS and Zhao Y
Tetrahedron Letters, 42, 1259-1262 (2001)
On the use of PyAOP, a phosphonium salt derived from HOAt, in solid-phase peptide synthesis
F. Albericio, et al.
Tetrahedron Letters, 38, 4853-4853 (1997)
Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains
Planas M, et al.
Tetrahedron Letters, 41, 4097-4100 (2000)
商品
Novabiochem®可提供大量的偶联剂用于原位活化。原位活化试剂易于使用 - 即使是利用空间位阻氨基酸，并且它们的使用通常没有副反应。
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
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