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![COMU 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®](/deepweb/assets/sigmaaldrich/product/images/237/337/13566c06-8931-4cc2-8621-c8742a392cd6/640/13566c06-8931-4cc2-8621-c8742a392cd6.jpg)
质量水平
产品线
Novabiochem®
表单
solid
反应适用性
reaction type: Coupling Reactions
制造商/商品名称
Novabiochem®
mp
104-109 °C
应用
peptide synthesis
储存温度
2-8°C
SMILES字符串
FC(=[N+](C)C)N(C)C
InChI
1S/C5H12FN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1
InChI key
JILUGXGJYPRQPA-UHFFFAOYSA-N
一般描述
TFFH is an in situ coupling reagents which smoothly converts protected amino acids to the corresponding acid fluoride in the presence of base [1]. Acid fluorides have proven are highly effective at coupling hindered amino acids such as α,α-disubstituted amino acids [2].
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] L. A. Carpino, et al. (1995) J. Am. Chem. Soc., 117, 5401.
[2] S. A. Triolo, et al. in ′Peptides 1996, Proc. of 24th European Peptide Symposium′, R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 839.
分析说明
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test
Appearance of substance (visual): powder
Assay 1H-qNMR: ≥ 98.0 %
Ratio Cation/anion in 19F-NMR integration: lot specific result
1:5,7 to 1:6,3
Identity (IR): passes test
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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