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![COMU 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®](/deepweb/assets/sigmaaldrich/product/images/237/337/13566c06-8931-4cc2-8621-c8742a392cd6/640/13566c06-8931-4cc2-8621-c8742a392cd6.jpg)
质量水平
产品线
Novabiochem®
方案
≥99.0% (HPLC)
表单
powder
效能
500-650 mg/kg LD50, oral (Rat)
反应适用性
reaction type: Coupling Reactions
制造商/商品名称
Novabiochem®
mp
142-148 °C
应用
peptide synthesis
储存温度
2-8°C
SMILES字符串
[B-](F)(F)(F)F.N([C+](N(C)C)ON=C(C(=O)OCC)C#N)(C)C
InChI
1S/C10H17N4O3.BF4/c1-6-16-9(15)8(7-11)12-17-10(13(2)3)14(4)5;2-1(3,4)5/h6H2,1-5H3;/q+1;-1
InChI key
FPQVGDGSRVMNMR-UHFFFAOYSA-N
一般描述
TOTU is an excellent alternative to HOBt-based coupling reagents such as HBTU and TBTU. It has high reactivity and is likely to have low allergenicity and low explosivity. The by-products of using this coupling reagent are water-soluble, making it an ideal choice for solution phase coupling reactions.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] G. Breipohl & W. Koenig, US patent 5166394.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] G. Breipohl & W. Koenig, US patent 5166394.
分析说明
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble
法律信息
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
商品
Novabiochem®可提供大量的偶联剂用于原位活化。原位活化试剂易于使用 - 即使是利用空间位阻氨基酸，并且它们的使用通常没有副反应。
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
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