8.51008
TBTU
≥98.0% (HPLC), for peptide synthesis, Novabiochem®
别名:
TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate
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关于此项目
经验公式（希尔记法）:
C11H16BF4N5O
化学文摘社编号:
分子量:
321.08
UNSPSC Code:
12352107
EC Index Number:
423-040-4
NACRES:
NA.22
MDL number:
产品名称
TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem®
SMILES string
[B+3].[F-].[F-].[F-].[F-].[N+](=C(N(C)C)O[n]1nnc2c1cccc2)(C)C
InChI
1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4
InChI key
SHGLJDNRZIDILW-UHFFFAOYSA-J
product line
Novabiochem®
assay
≥98.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
mp
195-199 °C (decomposes)
application(s)
peptide synthesis
storage temp.
15-25°C
Quality Level
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %
Application
- Synthesis of phospho-urodilatin by combination of global phosphorylation with the segment coupling approach.: This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996).
- Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.: The study investigates the impact of tertiary amines on carbodiimide-mediated peptide synthesis, highlighting the role of TBTU in enhancing peptide coupling efficiency (Beyermann et al., 1991).
General description
See entry for HBTU (851006). TBTU has been employed to generate 1,2,4-oxadiazoles from carboxylic acids [1].
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.
Other Notes
Replaces: 01-62-0015
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 1 - Skin Sens. 1A
存储类别
4.1A - Other explosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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