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蒸汽压
10 hPa ( 55 °C)
质量水平
表单
liquid
效能
1605 mg/kg LD50, oral (Rat)
>2000 mg/kg LD50, skin (Rat)
pH值（酸碱度）
<1 ( in H2O)
沸点
162 °C/1013 hPa
密度
1.71 g/cm3 at 20 °C
储存温度
2-30°C
SMILES字符串
[Ba+2].FC(F)(F)[S](=O)(=O)[O-].FC(F)(F)[S](=O)(=O)[O-]
InChI
1S/2CHF3O3S.Ba/c2*2-1(3,4)8(5,6)7;/h2*(H,5,6,7);/q;;+2/p-2
InChI key
DXJURUJRANOYMX-UHFFFAOYSA-L
一般描述
Trifluoromethanesulfonic acid (also known as Triflic acid, TFMSA or TfOH) is an organic acid that is commonly used as a reagent in organic synthesis due to its strong Bronsted acidity, finding applications in catalysis, N-protection, dehydration, activation, and addition reactions., TFMSA is also used for global deprotection and cleavage in Boc SPPS.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references:
[1] L. R. Subramanian, et al. (2001) Encyclopedia of Reagents for Organic Synthesis.
[2] R. D. Howells & J. D. Mc Cown JD (1977) Chem. Rev., 77, 69.
[3] J. Stewart, J. Young in “Solid Phase Peptide Synthesis”, Pierce Chemical Company, Rockford, 1984.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references:
[1] L. R. Subramanian, et al. (2001) Encyclopedia of Reagents for Organic Synthesis.
[2] R. D. Howells & J. D. Mc Cown JD (1977) Chem. Rev., 77, 69.
[3] J. Stewart, J. Young in “Solid Phase Peptide Synthesis”, Pierce Chemical Company, Rockford, 1984.
应用
Recent applications of trifluoromethanesulfonic acid include:
- A dehydrating agent for the conversion of secondary alcohols to alkene, or the preparation of anhydrides from carboxylic acids.
- An acid catalyst in the synthesis of carbohydrates and glycosides.
- An activating agent for the activation of carboxylic acids and can be used for the synthesis of carboxylic acid derivatives such as esters, amides, and anhydrides.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Met. Corr. 1 - Skin Corr. 1B - STOT SE 3
靶器官
Respiratory system
储存分类代码
8A - Combustible, corrosive hazardous materials
WGK
WGK 1
闪点(°F)
332.1 °F - Pensky-Martens closed cup
闪点(°C)
> 166.7 °C - Pensky-Martens closed cup
Trifluoromethanesulfonic acid and derivatives
R. D. Howells & J. D. Mc Cown JD
Chemical Reviews, 77, 69-69 (1977)
Highly efficient p-toluenesulfonic acid-catalyzed alcohol addition or hydration of unsymmetrical arylalkynes
Olivi N, et al.
Synlett, 2004, 2175-2179 (2004)
Solid Phase Peptide Synthesis, Pierce Chemical Company, Rockford, 1984.
J. Stewart, J. Young
Solid Phase Peptide Synthesis (1984)
L. R. Subramanian, et al.
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2001)
Effect of Lewis acid on catalytic dehydration of a chitin-derived sugar alcohol
Sagawa T, et al.
Molecular Catalysis, 111282-111282 (2020)
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