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Merck
CN

8.17072

TWEEN® 20（聚山梨酯）

EMPROVE® ESSENTIAL, Ph. Eur., JPE, NF

别名:

TWEEN ® 20, 聚氧乙烯山梨糖醇酐单月桂酸酯, 聚氧乙烯脱水山梨醇单月桂酸酯

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化学文摘社编号:
9005-64-5
UNSPSC Code:
12352104
EC Index Number:
500-018-3
MDL number:
MFCD00165986

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产品名称

TWEEN® 20（聚山梨酯）, EMPROVE® ESSENTIAL, Ph. Eur., JPE, NF

InChI

1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3

SMILES string

CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO

InChI key

HMFKFHLTUCJZJO-UHFFFAOYSA-N

agency

JPE
NF
Ph. Eur.

vapor pressure

<1.4 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

form

viscous liquid

mol wt

~1228

technique(s)

API processing | nano-milling: suitable

refractive index

n20/D 1.468 (lit.)

pH

6-8 (20 °C, 50 g/L in H2O)

transition temp

flash point 275 °C

density

1.095 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

storage temp.

15-25°C

Quality Level

500

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相关类别

Application

非离子洗涤剂
Polysorbate 20 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

527.0 °F - Pensky-Martens closed cup

flash_point_c

275 °C - Pensky-Martens closed cup

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Strategies for the Development of Safe and Effective Pediatric Formulations

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.

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Pediatric Formulations

Developing formulations specifically for infants and children is increasingly important. To help you master these challenges effectively, we offer an extensive portfolio of well-established high-quality excipients and APIs for pediatric pharmaceutical formulations that are proven in practice.

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