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安全信息

8.14815

Sigma-Aldrich

Sodium chlorite

(25% solution in water) for synthesis

别名:

Chlorous acid, sodium salt

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About This Item

UNSPSC代码:
12352302
NACRES:
NA.22
表单:
liquid

蒸汽压

20 hPa ( 20 °C)

质量水平

200

表单

liquid

效能

1136 mg/kg LD50, oral (Rat)

pH值（酸碱度）

12-13 (20 °C in H2O)

沸点

≥100 °C/1013 hPa

mp

<-3 °C

密度

1.20-1.25 g/cm3 at 20 °C

储存温度

2-30°C

应用

Sodium chlorite (NaClO2) can be used as an oxidizing agent for the conversion of:
  • Aldehydes to corresponding carboxylic acids under mild reaction conditions in the presence of scavengers such as sulfamic acid or resorcinol.
  • Primary alcohols to carboxylic acids in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and NaOCl.
  • Aliphatic and aromatic thiols to the corresponding disulfides.
  • Aryl boronic acids to phenols via ipso-hydroxylation.
  • Cyclic benzylic ethers and N-protected cyclic benzylic amines to benzolactones and benzolactams.
  • Alkenes to epoxides using aldehydes as promoters.
  • Alkenes and cycloalkenes to 1, 2 diols via osmium-catalyzed Sharpless asymmetric dihydroxylation.

It can also be used in combination with Br2 to synthesize 2-carboxyazetidin-2-ones from furanylazetidinones.

分析说明

Assay (iodometric): 23.0 - 26.0 %
Density (d 20 °C/ 4 °C): 1.200 - 1.220

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1 - STOT RE 2

靶器官

spleen

补充剂危害

EUH032

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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A simple and effective synthesis of benzolactones and benzolactams by noncatalytic benzylic oxidation of cyclic benzylic ethers and N-protected cyclic benzylic amines with sodium chlorite as an oxidant
Song Ai-Ru, et al.
Synthesis, 44(18), 2903-2909 (2012)
Uses of sodium chlorite and sodium bromate in organic synthesis. A review
Krapcho A Paul
Organic preparations and procedures international, 38(2), 177-216 (2006)
Epoxidation by sodium chlorite with aldehyde-promoted chlorine dioxide formation
Jangam A and Richardson DE
Tetrahedron Letters, 51(50), 6481-6484 (2010)
ipso-Hydroxylation of Arylboronic Acids and Boronate Esters by Using Sodium Chlorite as an Oxidant in Water
Gogoi P, et al.
European Journal of Organic Chemistry, 2013(32), 7291-7294 (2013)

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