681673
Wnt拮抗剂III，Box5
The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Wnt拮抗剂III，Box5
产品名称
Wnt拮抗剂III，Box5, The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
assay
≥90% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
water: 4 mg/mL
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Disclaimer
毒性：标准处理（A）
General description
一种Wnt-5a衍生的N-末端丁氧羰基-（Boc）保护的六肽，有效对抗A2058和HTB63黑色素瘤培养物中Wnt-5a介导的细胞活动，包括迁移、侵袭、钙反应和MARCKS磷酸化。用甲酰修饰取代N-末端Boc会产生一种称为Foxy5的肽，该肽以Frizzled-5-（Fzd-5/Frz-5）依赖的方式模拟而不是拮抗Wnt-5a的生物活性。肽序列在多个物种中都是保守的，包括人类、小鼠和大鼠，Box5有望通过直接FZD5结合发挥其作用，就像Foxy5一样。
Other Notes
Jenei, V., et al. 2009.Proc.Natl.Acad.Sci. USA106, 19473.
Safholm, A., et al. 2006.J. Biol. Chem.281, 2740.
Safholm, A., et al. 2006.J. Biol. Chem.281, 2740.
t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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