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Merck
CN
所有图片(1)

文件

681673

Sigma-Aldrich

Wnt拮抗剂III,Box5

The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

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别名:
Wnt拮抗剂III,Box5
经验公式(希尔记法):
C30H50N6O13S2
分子量:
766.88
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥90% (HPLC)

形式

lyophilized solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

water: 4 mg/mL
DMSO: 50 mg/mL

运输

wet ice

储存温度

−20°C

一般描述

一种Wnt-5a衍生的N-末端丁氧羰基-(Boc)保护的六肽,有效对抗A2058和HTB63黑色素瘤培养物中Wnt-5a介导的细胞活动,包括迁移、侵袭、钙反应和MARCKS磷酸化。用甲酰修饰取代N-末端Boc会产生一种称为Foxy5的肽,该肽以Frizzled-5-(Fzd-5/Frz-5)依赖的方式模拟而不是拮抗Wnt-5a的生物活性。肽序列在多个物种中都是保守的,包括人类、小鼠和大鼠,Box5有望通过直接FZD5结合发挥其作用,就像Foxy5一样。

包装

用惰性气体包装

警告

毒性:标准处理(A)

序列

t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H

重悬

复溶后,等分并冷冻保存(-20°C)。贮备溶液在-20°C下可稳定保存至多3个月。

其他说明

Jenei, V., et al. 2009.Proc.Natl.Acad.Sci. USA106, 19473.
Safholm, A., et al. 2006.J. Biol. Chem.281, 2740.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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