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质量水平
方案
≥90% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 4 mg/mL
DMSO: 50 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
一种Wnt-5a衍生的N-末端丁氧羰基-（Boc）保护的六肽，有效对抗A2058和HTB63黑色素瘤培养物中Wnt-5a介导的细胞活动，包括迁移、侵袭、钙反应和MARCKS磷酸化。用甲酰修饰取代N-末端Boc会产生一种称为Foxy5的肽，该肽以Frizzled-5-（Fzd-5/Frz-5）依赖的方式模拟而不是拮抗Wnt-5a的生物活性。肽序列在多个物种中都是保守的，包括人类、小鼠和大鼠，Box5有望通过直接FZD5结合发挥其作用，就像Foxy5一样。
包装
用惰性气体包装
警告
毒性：标准处理（A）
序列
t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Jenei, V., et al. 2009.Proc.Natl.Acad.Sci. USA106, 19473.
Safholm, A., et al. 2006.J. Biol. Chem.281, 2740.
Safholm, A., et al. 2006.J. Biol. Chem.281, 2740.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Krishan G Jain et al.
American journal of physiology. Lung cellular and molecular physiology, 323(5), L515-L524 (2022-09-14)
Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells for re-alveolarization has not been studied.
Yiming Fang et al.
NPJ precision oncology, 8(1), 7-7 (2024-01-09)
Frequent relapse and chemoresistance cause poor outcome in ovarian cancer (OC) and cancer stem cells (CSCs) are important contributors. While most studies focus exclusively on CSCs, the role of the microenvironment in providing optimal conditions to maintain their tumor-initiating potential
Chao Liu et al.
Science advances, 9(4), eadd8977-eadd8977 (2023-01-28)
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions remain. We performed single-cell RNA
Deciphering the impacts of modulating the Wnt-planar cell polarity (PCP) pathway on alveolar repair.
Sally Yunsun Kim et al.
Frontiers in cell and developmental biology, 12, 1349312-1349312 (2024-03-13)
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associated with lung diseases including emphysema, idiopathic
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