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质量水平
检测方案
≥97% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 2.5 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChI key
WRKPZSMRWPJJDH-UHFFFAOYSA-N
一般描述
一种细胞渗透性苯并噻唑基乙酰胺化合物，通过选择性阻断MBOAT（膜结合O-酰基转移酶）家族成员Porcn-（Porcupine）介导的Wnt棕榈酰化作用抑制细胞Wnt加工和分泌。IWP-2一般不影响Wnt/β-连环蛋白信号通路，与IWR-1-endo（目录号681669）不同，IWP-2对Wnt刺激的细胞反应没有影响。也可以10 mM的DMSO溶液（目录号506072）提供。
一种细胞渗透性苯并噻唑基乙酰胺化合物，通过选择性阻断MBOAT（膜结合O-酰基转移酶）家族成员Porcn-（Porcupine）介导的Wnt棕榈酰化作用抑制细胞Wnt加工和分泌。IWP-2一般不影响Wnt/β-连环蛋白信号通路，与IWR-1-endo（目录号681669）不同，IWP-2对Wnt刺激的细胞反应没有影响。
包装
用惰性气体包装
警告
毒性：有害（C）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Chen, B., et al. 2009.Nature Chem. Biol.5, 100.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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