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Merck
CN
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主要文件

681664

Sigma-Aldrich

Wnt Agonist I in DMSO

The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

Wnt Agonist I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO, Wnt Pathway Activator I in DMSO, 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine

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About This Item

经验公式(希尔记法):
C19H18N4O3
分子量:
350.37
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥95% (HPLC)

表单

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

运输

ambient

储存温度

−70°C

SMILES字符串

NC1=NC(NCC2=CC=C(OCO3)C3=C2)=CC(C4=CC=CC(OC)=C4)=N1

InChI

1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)

InChI key

FABQUVYDAXWUQP-UHFFFAOYSA-N

一般描述

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.

生化/生理作用

Cell permeable: yes
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

其他说明

Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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