681641
Wee1 Inhibitor II
The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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别名:
Wee1 Inhibitor II, 6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
经验公式（希尔记法）:
C24H19ClN2O3
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质量水平
检测方案
≥97% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
brown
溶解性
DMSO: 10 mg/mL
ethanol: 10 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
生化/生理作用
Cell permeable: no
Primary Target
Wee1
Wee1
Product does not compete with ATP.
Reversible: no
Target IC50: 59 nM against Wee1
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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