681629
W-7盐酸盐
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).
别名:
W-7盐酸盐, N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H21ClN2O2S · xHCl
CAS号:
分子量:
340.87 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥98% (TLC)
表单
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
off-white
溶解性
DMSO: 5 mg/mL
DMF: soluble
warm ethanol: soluble
运输
ambient
储存温度
2-8°C
SMILES字符串
[S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI key
OMMOSRLIFSCDBL-UHFFFAOYSA-N
一般描述
一种细胞渗透性和可逆性钙调蛋白拮抗剂，可抑制肌球蛋白轻链激酶（IC50 = 51 µM）和Ca2+-钙调蛋白依赖性磷酸二酯酶（IC50 = 28 µM）。
一种细胞渗透性和可逆性钙调蛋白拮抗剂，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶（C50 = 28 µM）和肌球蛋白轻链激酶（IC50 = 51 µMM）。
生化/生理作用
主靶
肌球蛋白轻链激酶
肌球蛋白轻链激酶
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：51µM，抑制肌球蛋白轻链激酶；28µM，抑制Ca2+-钙调蛋白依赖性磷酸二酯酶
警告
毒性：标准处理（A）
其他说明
Caulfield, M.P., et al. 1991.Neurosci. Lett.125, 57.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
Asano, M. 1989.J. Pharmacol.Exp.Ther.251, 764.
Itoh, H., and Hidaka, H. 1984.J. Biochem.96, 1721.
Tanaka, T., et al. 1983.Pharmacol.26, 249.
Hidaka, H. 1981.Proc.Natl.Acad.Sci. USA 78, 4354.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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