681625
W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).
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别名:
W-5, Hydrochloride, N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
经验公式（希尔记法）:
C16H22N2O2S · xHCl
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质量水平
检测方案
≥98% (NMR)
形式
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
溶解性
DMSO: soluble
water: soluble
运输
ambient
储存温度
2-8°C
InChI
1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChI key
HOCSVIGHWPLMFC-UHFFFAOYSA-N
一般描述
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
警告
Toxicity: Standard Handling (A)
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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