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主要文件

COA分析证书/COQ

681535

Withaferin A

Name: Withaferin A
Brand: MM

from Withania somnifera, ≥94% (HPLC), solid, anti-inflammatory lactone, Calbiochem^®

别名:

Withaferin A, Withania somnifera

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About This Item

经验公式（希尔记法）:

C₂₈H₃₈O₆

CAS号:

5119-48-2

分子量:

470.60

MDL编号:

MFCD10687098

UNSPSC代码:

12352200

NACRES:

NA.77

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Sigma-Aldrich

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Sigma-Aldrich

D2438

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产品名称

Withaferin A, Withania somnifera, A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

质量水平

100

描述

RTECS - KE7288500

方案

≥94% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 10 mg/mL
ethanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

O1[C@H](CC(=C(C1=O)CO)C)[C@H]([C@@H]2[C@@]3([C@H]([C@H]4[C@@H]([C@@]5([C@@]6(O[C@@H]6C4)[C@H](C=CC5=O)O)C)CC3)CC2)C)C

InChI

1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI key

DBRXOUCRJQVYJQ-CKNDUULBSA-N

一般描述

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.

生化/生理作用

Cell permeable: yes

Primary Target
A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

其他说明

Mohan, R., et al. 2004. Angiogenesis7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci.74, 125.
Devi, P.U., et al. 1995. Cancer Lett.95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

438.8 °F

闪点(°C)

226 °C

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主要文件

Withaferin A