推荐产品
质量水平
检测方案
≥98% (TLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
water: 20 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
InChI key
AQTQHPDCURKLKT-JKDPCDLQSA-N
一般描述
Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Indole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Carcinogenic / Teratogenic (D)
其他说明
Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Muta. 2 - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines.
Katrin Ullrich et al.
British journal of haematology, 155(3), 398-402 (2011-04-27)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门