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Merck
CN
所有图片(1)

主要文件

677175-M

Millipore

Vinblastine Sulfate

Antitumor alkaloid drug.

别名:

Vinblastine Sulfate

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About This Item

经验公式（希尔记法）:
C46H58N4O9 · xH2SO4
CAS号:
143-67-9
分子量:
810.97 (free base basis)
MDL编号:
MFCD00082457
UNSPSC代码:
12352200

质量水平

100

方案

≥98% (HPLC)

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated
protect from light

颜色

white

溶解性

water: 50 mg/mL

储存温度

2-8°C

SMILES字符串

[S](=O)(=O)(O)O.N21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@@H]5[C@]64[C@H]7N(CC6)CC=C[C@]7([C@H]([C@]5(O)C(=O)OC)OC(=O)C)CC)C)C(=O)OC

InChI

1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChI key

KDQAABAKXDWYSZ-JKDPCDLQSA-N

一般描述

Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes.
Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.

生化/生理作用

Primary Target
Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Tanaka, E., et al. 1995. J. Cell. Biol.128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 374.
Smith, C.D., et al. 1994. Cancer Lett.79, 213.
Smith, C.D., et al. 1994. Cancer Res.54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res.280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem.11, 509.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H302,H341,H361fd

危险分类

Acute Tox. 4 Oral - Muta. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

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