676777
(±)-Verapamil, Hydrochloride
A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.
别名:
(±)-Verapamil, Hydrochloride, L-Type Calcium Channel Blocker V
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About This Item
经验公式（希尔记法）:
C27H38N2O4 · xHCl
CAS号:
分子量:
454.60 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
描述
Merck USA index - 14, 9950
方案
≥99% (perchloric acid titration)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
methanol: 50 mg/mL
water: 70 mg/mL
ethanol: soluble
运输
ambient
储存温度
10-30°C
SMILES字符串
[Cl-].[N+H](CCCC(C(C)C)(c2cc(c(cc2)OC)OC)C#N)(CCc1cc(c(cc1)OC)OC)C
InChI
1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChI key
DOQPXTMNIUCOSY-UHFFFAOYSA-N
一般描述
A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Toxic (F)
其他说明
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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