推荐产品
产品名称
VEGFR3激酶抑制剂，MAZ51, The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
red
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O
InChI
1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChI key
VFCXONOPGCDDBQ-UHFFFAOYSA-N
一般描述
一种细胞可渗透的3-取代吲哚-2-酮化合物，可作为VEGF受体酪氨酸激酶的可逆和ATP竞争性抑制剂。在低浓度（5 µM）下，据报道可在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。据报道，仅在较高浓度（50 µM）时部分阻断VEGFR-2磷酸化。这种差异抑制可能有助于控制淋巴管生成依赖性的肿瘤转移，因此对癌症治疗研究具有临床意义。
生化/生理作用
主靶
受体酪氨酸激酶
受体酪氨酸激酶
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：在低浓度（≤5 µM）下，它在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。
包装
用惰性气体包装
警告
毒性：标准处理（A）
其他说明
Kirkin, V., et al. 2001.Eur. J. Biochem.268, 5530
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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