所有图片(1)
别名:
VEGFR3激酶抑制剂，MAZ51, MAZ51，3-(4-二甲氨基-萘-1-基亚甲基)-1,3-二氢-吲哚-2-酮，血管内皮生长因子受体3激酶抑制剂，VEGFR酪氨酸激酶抑制剂XVI，VEGFR3激酶抑制剂I
经验公式（希尔记法）:
C21H18N2O
推荐产品
product name
VEGFR3激酶抑制剂，MAZ51, The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
red
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChI key
VFCXONOPGCDDBQ-UHFFFAOYSA-N
一般描述
一种细胞可渗透的3-取代吲哚-2-酮化合物，可作为VEGF受体酪氨酸激酶的可逆和ATP竞争性抑制剂。在低浓度（5 µM）下，据报道可在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。据报道，仅在较高浓度（50 µM）时部分阻断VEGFR-2磷酸化。这种差异抑制可能有助于控制淋巴管生成依赖性的肿瘤转移，因此对癌症治疗研究具有临床意义。
生化/生理作用
主靶
受体酪氨酸激酶
受体酪氨酸激酶
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：在低浓度（≤5 µM）下，它在PAE细胞中特异性阻断VEGF-C和VEGF-D诱导的VEGFR-3磷酸化，而不是VEGFR-2磷酸化。
包装
用惰性气体包装
警告
毒性：标准处理（A）
其他说明
Kirkin, V., et al. 2001.Eur. J. Biochem.268, 5530
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Pu-Hong Zhang et al.
JCI insight, 9(1) (2023-11-17)
The lymphatic vasculature is the natural pathway for the resolution of inflammation, yet the role of pulmonary lymphatic drainage function in sepsis-induced acute respiratory distress syndrome (ARDS) remains poorly characterized. In this study, indocyanine green-near infrared lymphatic living imaging was
Jinman Chen et al.
Nature communications, 11(1), 3159-3159 (2020-06-24)
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in
Raj Kumar et al.
Cell death & disease, 11(5), 325-325 (2020-05-10)
Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization. Based on these clues, we have studied the role of PKCθ
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门