product name
丙戊酸钠盐, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).
质量水平
检测方案
≥98% (HPLC)
形式
solid
效能
400 μM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
颜色
white
溶解性
water: 50 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
一般描述
一种细胞可渗透性短链脂肪酸，可抑制组蛋白脱乙酰酶活性（HDAC1的IC50 = 400 µM）。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平（350 µM-1.04 mM），引起肌醇耗竭，抑制GSK-3α和-3β，激活ERK通路，并产生神经营养效应。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体（PPAR）活性。在人类和啮齿动物模型中显示出强效的致畸活性。
一种细胞渗透性短链脂肪酸，可抑制组蛋白脱乙酰酶（HDAC1的IC50 = 400 µM）。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平（0.35 mM-1.04 mM），引起肌醇耗竭，抑制GSK-3α和-3β，激活ERK通路并产生神经营养作用。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体（PPAR）活性。在人类和啮齿动物模型中显示出强效的致畸活性。
生化/生理作用
主要靶标
HDAC1
HDAC1
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
包装
用惰性气体包装
警告
毒性：有害 & 致癌/致畸性（E）
其他说明
Gottlicher, M., et al. 2001.EMBO J.20, 6969.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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