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Merck
CN
所有图片(1)

文件

672999

Sigma-Aldrich

V-ATPase Inhibitor, KM91104

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别名:
V-ATPase Inhibitor, KM91104, H+-ATPase Inhibitor
经验公式(希尔记法):
C14H12N2O4
分子量:
272.26
UNSPSC代码:
12352200
NACRES:
NA.28

检测方案

>98% (HPLC)

质量水平

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

−20°C

一般描述

A cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC50 of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kartner, N., et al. 2010. J. Biol. Chem.285, 37476.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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