662142
DUB抑制剂VI，P22077
The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
DUB抑制剂VI，P22077, USP7抑制剂II， USP47抑制剂II，P022077，1-(5-(2,4-二氟苯基硫基)-4-硝基噻吩-2-硝基)噻吩
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H7F2NO3S2
化学文摘社编号:
分子量:
315.32
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
产品名称
DUB抑制剂VI，P22077, The DUB Inhibitor VI, P22077 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
InChI key
RMAMGGNACJHXHO-UHFFFAOYSA-N
SMILES string
CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Disclaimer
毒性：标准处理（A）
General description
一种细胞可渗透的噻吩基乙酮化合物，可抑制USP7和USP47去泛素化酶活性（IC50分别为8.01&和8.74 µM），同时对ATXN3、BAP1和USP1的亲和力大大降低，对其他已知PR-619（目录号662141）靶标（IC50 >50 µM）无抑制活性。P22077和PR-619均显示以剂量和时间依赖性方式（20至150 µM；0.5至20 h）增加HEK293T细胞中的整体蛋白多泛素化，然而，PR619处理导致K48-和K63-连接的上调，而P22077暴露主要导致K48-连接的多聚泛素链的富集。
Other Notes
Altun, M., et al. 2011.Chem. Biol.18, 1401.
Tian, X., et al. 2011.Assay Drug Dev.Technol.9, 165.
Tian, X., et al. 2011.Assay Drug Dev.Technol.9, 165.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
André Franz et al.
Cell reports, 37(2), 109819-109819 (2021-10-14)
The AAA+ ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active DNA synthesis is associated with a SUMO-high/ubiquitin-low environment governed by the deubiquitylase USP7. Here, we unveil a functional
Joonyoung Her et al.
The Journal of clinical investigation, 134(10) (2024-03-26)
The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in
Sandhini Saha et al.
Cell death & disease, 13(6), 563-563 (2022-06-23)
Nutrient surplus and consequent free fatty acid accumulation in the liver cause hepatosteatosis. The exposure of free fatty acids to cultured hepatocyte and hepatocellular carcinoma cell lines induces cellular stress, organelle adaptation, and subsequent cell death. Despite many studies, the
相关内容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持