662141
PR-619
≥99% (HPLC), solid, DUB inhibitor, Calbiochem®
别名:
DUB抑制剂V，PR-619, UCH-L3抑制剂II，UCH-L5/UCH37抑制剂III，USP5抑制剂II，USP7抑制剂I，USP9X抑制剂II，USP14抑制剂IV，USP14抑制剂IV，USP47抑制剂I，2,6-二氨基吡啶-3,5-双（硫氰酸盐），3,5-二硫氰基吡啶-2,6-二胺，PR619，UC
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C7H5N5S2
分子量:
223.28
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
产品名称
DUB抑制剂V，PR-619, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light beige to yellow
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种细胞渗透性吡啶胺类广谱DUB抑制剂，其已知靶标包括ATXN3、BAP1、JOSD2、OTUD5、UCH-L1、UCH-L3、UCH-L5/UCH37、USP1、2、4、5、7、8、9X、10、14、15、16、19、20、22、24、28、47、48、VCIP135、YOD1，以及deISGylase PLpro、deNEDDylase DEN1和deSUMOlyase SENP6。PR-619和P22077（目录号662142）均显示以剂量和时间依赖性方式（20至150 µM；0.5至20 h）增加HEK293T细胞中的整体蛋白多聚泛素化，然而P22077暴露主要导致K48连接的富集，而PR619处理导致K48和K63连接的多聚亚基链的上调。
包装
用惰性气体包装
警告
毒性：标准处理（A）
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Alessandro Dario Confettura et al.
Translational neurodegeneration, 11(1), 2-2 (2022-01-07)
The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It has been proposed that neuroinflammation
Kim Ghilarducci et al.
International journal of molecular sciences, 23(14) (2022-07-28)
Rab7 is a GTPase that controls late endosome and lysosome trafficking. Recent studies have demonstrated that Rab7 is ubiquitinated, a post-translational modification mediated by an enzymatic cascade. To date, only one ubiquitin E3 ligase and one deubiquitinase have been identified
Michelle Mølgaard Thomsen et al.
Journal of clinical immunology, 44(2), 56-56 (2024-01-26)
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated
Yaara Makaros et al.
Molecular cell, 83(11), 1921-1935 (2023-05-19)
Although most eukaryotic proteins are targeted for proteasomal degradation by ubiquitination, a subset have been demonstrated to undergo ubiquitin-independent proteasomal degradation (UbInPD). However, little is known about the molecular mechanisms driving UbInPD and the degrons involved. Utilizing the GPS-peptidome approach
Sofia Lachiondo-Ortega et al.
Cell reports, 43(3), 113924-113924 (2024-03-20)
The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is SUMOylated in
相关内容
Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门