662141
PR-619
≥99% (HPLC), solid, DUB inhibitor, Calbiochem®
别名:
DUB抑制剂V，PR-619, UCH-L3抑制剂II，UCH-L5/UCH37抑制剂III，USP5抑制剂II，USP7抑制剂I，USP9X抑制剂II，USP14抑制剂IV，USP14抑制剂IV，USP47抑制剂I，2,6-二氨基吡啶-3,5-双（硫氰酸盐），3,5-二硫氰基吡啶-2,6-二胺，PR619，UC
产品名称
DUB抑制剂V，PR-619, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
light beige to yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Disclaimer
毒性：标准处理（A）
General description
一种细胞渗透性吡啶胺类广谱DUB抑制剂，其已知靶标包括ATXN3、BAP1、JOSD2、OTUD5、UCH-L1、UCH-L3、UCH-L5/UCH37、USP1、2、4、5、7、8、9X、10、14、15、16、19、20、22、24、28、47、48、VCIP135、YOD1，以及deISGylase PLpro、deNEDDylase DEN1和deSUMOlyase SENP6。PR-619和P22077（目录号662142）均显示以剂量和时间依赖性方式（20至150 µM；0.5至20 h）增加HEK293T细胞中的整体蛋白多聚泛素化，然而P22077暴露主要导致K48连接的富集，而PR619处理导致K48和K63连接的多聚亚基链的上调。
Packaging
用惰性气体包装
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
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International journal of molecular sciences, 23(14) (2022-07-28)
Rab7 is a GTPase that controls late endosome and lysosome trafficking. Recent studies have demonstrated that Rab7 is ubiquitinated, a post-translational modification mediated by an enzymatic cascade. To date, only one ubiquitin E3 ligase and one deubiquitinase have been identified
Alessandro Dario Confettura et al.
Translational neurodegeneration, 11(1), 2-2 (2022-01-07)
The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It has been proposed that neuroinflammation
Michelle Mølgaard Thomsen et al.
Journal of clinical immunology, 44(2), 56-56 (2024-01-26)
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated
Yaara Makaros et al.
Molecular cell, 83(11), 1921-1935 (2023-05-19)
Although most eukaryotic proteins are targeted for proteasomal degradation by ubiquitination, a subset have been demonstrated to undergo ubiquitin-independent proteasomal degradation (UbInPD). However, little is known about the molecular mechanisms driving UbInPD and the degrons involved. Utilizing the GPS-peptidome approach
Kim Ghilarducci et al.
The FEBS journal, 288(16), 4849-4868 (2021-03-03)
Protein ubiquitination has been historically associated with protein degradation, but recent studies have demonstrated other cellular functions associated with substrate ubiquitination. Among the RING-type ubiquitin E3 ligase enzymes present in the human genome, RNF167 is a transmembrane protein located in
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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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