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方案
≥97% (sum of two isomers, HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 200 mg/mL
储存温度
2-8°C
一般描述
A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
生化/生理作用
Primary Target
TrkA
TrkA
Target IC50: 63 nM against TrkA
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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