647926-M
Trichostatin A, Streptomyces sp.
InSolution, ≥98%, reversible inhibitor of histone deacetylase
别名:
InSolution Trichostatin A, Streptomyces sp., 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA
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About This Item
经验公式（希尔记法）:
C17H22N2O3
分子量:
302.37
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
储存温度
−20°C
一般描述
A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.
生化/生理作用
Primary Target
histone deactylase
histone deactylase
Target IC50: 73 nM inhibiting IL-2 gene expression in Jurkat cells
警告
Toxicity: Harmful (C)
外形
A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
闪点(°C)
87 °C - closed cup - (Dimethylsulfoxide)
法规信息
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