推荐产品
检测方案
≥97% (SDS-PAGE)
质量水平
形式
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
杂质
≤1 EU/μg Endotoxin (EU/μg TGF-β1)
运输
ambient
储存温度
−20°C
一般描述
CHO细胞中表达的重组人转化生长因子β1。可促进静息的人B淋巴细胞、神经胶质瘤细胞和三叉神经鞘瘤细胞的凋亡。在各种疾病中诱导细胞外基质积聚。
生化/生理作用
ED₅₀ = 0.04-0.1 ng/ml
警告
毒性：标准处理（A）
外形
由含50 µg BSA/µg TGF-β1、35％乙腈、0.1％TFA的无菌滤过溶液冻干。
重悬
溶解后，分装并冷冻保存（-20°C）。避免溶液反复冻融。储备溶液在-20°C下可稳定保存至多3个月。
用含有≥0.1％ HSA或BSA的4 mM无菌HCl复溶成浓度≥1 µg/m的溶液。
其他说明
Shibuya, H., et al. 1996.Science272, 1179.
Bottlinger, E.P., et al. 1995.Proc.Natl.Acad.Sci. USA93, 5877.
Lomo, J., et al. 1995.J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995.Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994.Am. J. Pathol.144, 221.
Bottlinger, E.P., et al. 1995.Proc.Natl.Acad.Sci. USA93, 5877.
Lomo, J., et al. 1995.J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995.Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994.Am. J. Pathol.144, 221.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
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Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes.
Holly B Hindman et al.
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