616453
TGF-β RI Kinase Inhibitor III
The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
TGF-β RI Kinase Inhibitor III, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
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About This Item
经验公式（希尔记法）:
C20H21N3O2 · xHCl
CAS号:
分子量:
335.40 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
light yellow
溶解性
DMSO: 20 mg/mL
water: 3 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
Cl.[nH]1c(nc(c1c3cc4c(cc3)OCO4)c2nc(ccc2)C)C(C)(C)C
InChI
1S/C20H21N3O2.ClH/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;/h5-10H,11H2,1-4H3,(H,22,23);1H
InChI key
BTUOOXPZOVNPMF-UHFFFAOYSA-N
一般描述
A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
生化/生理作用
Cell permeable: yes
Primary Target
Activin receptor-like kinase 4, 5, 7
Activin receptor-like kinase 4, 5, 7
Product competes with ATP.
Reversible: yes
Target IC50: 129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
包装
Packaged under inert gas
警告
Toxicity: Irritant (B)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol.289, F816.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.
DaCosta Byfield, S., et al. 2004. Mol. Pharmacol.65, 744.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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