616403
TACE Substrate III, Fluorogenic
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE (Km = 19 µM).
别名:
TACE Substrate III, Fluorogenic, TNF-α Convertase Enzyme Substrate II, Fluorogenic, ADAM-17 Substrate II, Fluorogenic, DABCYL-LAQAVRSSSR-EDANS, TNF-α Convertase Enzyme Substrate II, Fluorogenic, DABCYL-LAQAVRSSSR-EDANS, ADAM-17 Substrate II, Fluorogenic
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About This Item
推荐产品
质量水平
方案
≥95% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
red
溶解性
50% acetic acid: 5 mg/mL
DMSO: 5 mg/mL
荧光
λex ~340 nm
λem ~490 nm
运输
ambient
储存温度
−20°C
一般描述
A fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). Cleavage occurs between the alanine and valine residues. Useful for screening TACE inhibitors. Excitation max: ~340 nm; emission max: ~490 nm.
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE (Km = 19 µM). Substrate cleavage occurs at the Ala-Val bond. Useful for the screening of TACE and SARS protease 3-CLPRO inhibitors.
生化/生理作用
Cell permeable: no
Km = 19 µM as a fluorescence resonance energy transfer (FRET) peptide substrate for TACE
Primary Target
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE
Product does not compete with ATP.
Reversible: no
包装
Yes
警告
Toxicity: Standard Handling (A)
序列
DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Bacha, U., et al. 2004. Biochemistry43, 4906.
Patel, I.R., et al. 1998. J. Immunol.160, 4570.
Patel, I.R., et al. 1998. J. Immunol.160, 4570.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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