检测方案
≥97% (titration)
质量水平
形式
solid
反应适用性
reagent type: chelator
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
tan
溶解性
ethanol: 10 mg/mL
0.1 M phosphate pH 7.0: 25 μM
DMSO: soluble
运输
ambient
储存温度
15-25°C
InChI
1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChI key
CVRXLMUYFMERMJ-UHFFFAOYSA-N
相关类别
一般描述
脂溶性重金属螯合剂，可穿过人工膜和天然膜。某些技术中用于测量细胞内游离Ca2+水平的辅助试剂。也可用于从阿尔茨海默’病脑组织中提取Aβ淀粉样沉积物。对重金属有极高的亲和力，但对Ca2+和Mg2+的亲和力较低。与Zn2+螯合时诱导DNA断裂，并诱导胸腺细胞凋亡。从脂质体捕获的QUIN 2（目录号551826）中去除重金属。
脂溶性重金属螯合剂，可穿过人工膜和天然膜。某些技术中用于测量细胞内游离Ca2+的辅助试剂。对重金属有极高的亲和力，但对Ca2+和Mg2+的亲和力较低。与Zn2+螯合时诱导DNA断裂，并导致胸腺细胞凋亡。从脂质体捕获的QUIN 2中去除重金属。显示在从阿尔茨海默′病脑组织中提取Aβ沉积物是有用的。
应用
- Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis.: This study investigates the role of poly(ADP-ribosyl)ation of the tumor suppressor protein p53 in neuronal apoptosis induced by TPEN, highlighting mechanisms of cell death in neurodegenerative diseases (Kim HL et al., 2015).
- Essential role of p53 in TPEN-induced neuronal apoptosis.: This article explores the critical involvement of the p53 protein in apoptosis initiated by TPEN in neuronal cells, offering insights into potential therapeutic targets for neuroprotection (Ra H et al., 2009).
- Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore.: Demonstrates how Clioquinol, similar to TPEN, functions as a zinc ionophore to induce autophagy, particularly in neurological contexts, which may be relevant for understanding TPEN′s mechanisms (Park MH et al., 2011).
警告
毒性：标准处理（A）
重悬
复溶后，等分并在惰性气体下冷冻（-20°C）。或者，用盐酸酸化（pH ≤3），以便长期贮藏。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Fonte, J., et al. 2001.J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999.J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995.Biochem.J.312, 919.
Jiang, S., et al. 1995.Lab. Invest.73, 111.
Sheridan, R.E. and Deshpande, S.S.1995.Toxicon33, 539.
McCabe, M.J., et al. 1993.Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992.J. Biol. Chem.267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp.Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989.J. Cellular Physiol.138, 593.
Raspe, E., et al. 1989.Eur. J. Pharmacol.163, 345.
Arslan, L.P., et al. 1985.J. Biol. Chem.260, 2719.
Cherny, R.A., et al. 1999.J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995.Biochem.J.312, 919.
Jiang, S., et al. 1995.Lab. Invest.73, 111.
Sheridan, R.E. and Deshpande, S.S.1995.Toxicon33, 539.
McCabe, M.J., et al. 1993.Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992.J. Biol. Chem.267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp.Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989.J. Cellular Physiol.138, 593.
Raspe, E., et al. 1989.Eur. J. Pharmacol.163, 345.
Arslan, L.P., et al. 1985.J. Biol. Chem.260, 2719.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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