613570
TIRAP Inhibitor Peptide, Cell-Permeable
The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
别名:
TIRAP Inhibitor Peptide, Cell-Permeable, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, Ant-Tirap 138-151, TIRAP Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
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所有图片(1)
About This Item
经验公式（希尔记法）:
C163H268N52O38S
分子量:
3596.26
UNSPSC代码:
12352202
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
lyophilized solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
DMSO: 5 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
A synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
生化/生理作用
Cell permeable: yes
Primary Target
LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Toshchakov, V., et al. 2002. Nat. Immunol.3, 392.
Fitzgerald, K.A., et al. 2001. Nature413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol.2, 828.
Horng, T., et al. 2001. Nat. Immunol.2, 835.
Fitzgerald, K.A., et al. 2001. Nature413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol.2, 828.
Horng, T., et al. 2001. Nat. Immunol.2, 835.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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