推荐产品
产品名称
TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).
质量水平
方案
≥90% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
purple
溶解性
water: 1 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3
InChI key
AKZFRMNXBLFDNN-UHFFFAOYSA-K
一般描述
一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在四链体DNA存在下发出强烈荧光。
一种有效的人类端粒酶抑制剂（IC50 = 6.5 µM）。TMPyP4通过堆叠在四链体核心的G-四联体上与DNA四链体紧密结合，导致端粒酶抑制。在有四链体DNA存在时发出高荧光。
生化/生理作用
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
靶标IC50：6.5 µM抑制人端粒酶
警告
毒性：标准处理（A）
其他说明
Yamashita, T., et al. 2005.Bioorg.Med. Chem.13, 2433.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
Izbicka, E., et al. 1999.Cancer Res. 59, 639.
Anantha, N.V., et al. 1998.Biochemistry 37, 2709.
Arthanari, H., et al. 1998.Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998.J. Am. Chem. Soc.120, 3261.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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