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生物来源
bovine
质量水平
表单
lyophilized
比活
≥1800 NIH units/mg protein
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
溶解性
water: soluble
运输
ambient
储存温度
−20°C
一般描述
凝血酶是钠激活的II型酶。这种丝氨酸蛋白酶包含两个阴离子结合的外源性位点，即ABE-I和ABE-II。凝血酶由酶原凝血酶原（因子II）在肝脏中合成。牛A-凝血酶由轻链（A链）和重链（B链）组成。这两条链通过非共价相互作用和一个双硫键连接。
应用
牛用高活性凝血酶已用于：
- 刺激LNCaP细胞和研究G-蛋白-偶联受体（GPCR）活性的影响
- 纤维蛋白凝胶制备
- 通过纤维蛋白原凝胶法制备纤维蛋白原凝胶
生化/生理作用
凝血酶可将纤维蛋白原转换成纤维蛋白并激活因子V、VIII、XI和XIII。它可促进血小板活化和血管收缩。凝血酶可稳定纤维蛋白聚合物。它在凝血级联系统的最后阶段起着至关重要的作用。
警告
毒性：有害（C）
外形
使用200 mM NaCl、50 mM枸橼酸盐缓冲液、1 ml 0.1% PEG（pH 6.5）冷冻干燥。
分析说明
通过SDS-PAGE从均质凝血酶原完成激活
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Segall JA and Liem TK
Congenital and Acquired Hypercoagulable Syndromes, 339-346 (2007)
Kitchens CS, et al.
Consultative Hemostasis and Thrombosis null
Isis S R Carter et al.
Thrombosis, 2010, 416167-416167 (2010-01-01)
Although prothrombin is one of the most widely studied enzymes in biology, the role of the thrombin A-chain has been neglected in comparison to the other domains. This paper summarizes the current data on the prothrombin catalytic domain A-chain region
Diana L Diesen et al.
Vascular, 16 Suppl 1, S29-S36 (2008-03-01)
Thrombin is a common hemostatic drug used in surgical practice for over 100 years because of its simplicity and efficacy. Thrombin converts fibrinogen to fibrin, activates platelets, and induces vascular contraction. It is available in multiple forms, including human thrombin
Madhavi A Jadhav et al.
Biochemistry, 49(13), 2918-2924 (2010-03-12)
The formation of a blood clot involves the interplay of thrombin, fibrinogen, and Factor XIII. Thrombin cleaves fibrinopeptides A and B from the N-termini of the fibrinogen Aalpha and Bbeta chains. Fibrin monomers are generated that then polymerize into a
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