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Merck
CN
所有图片(1)

文件

584222

Millipore

四氢尿苷

Potent competitive inhibitor of cytidine deaminase. Also available as a 100 mM solution in H2O.

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所有图片(1)
别名:
四氢尿苷
经验公式（希尔记法）:
C9H16N2O6
CAS号:
18771-50-1
分子量:
248.23
UNSPSC代码:
12352208
NACRES:
NA.51

质量水平

100

检测方案

≥90% (TLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

white to off-white

溶解性

water: 200 mg/mL

运输

wet ice

储存温度

−20°C

InChI

1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

InChI key

UCKYOOZPSJFJIZ-XVKVHKPRSA-N

相关类别

一般描述

一种胞苷脱氨酶的有效竞争性抑制剂。与阿糖胞苷（Ara-C）联合使用，在体外研究中评估Ara-C的抗白血病活性和抗肿瘤活性。
胞苷脱氨酶的有效竞争抑制剂。也可以100 mM H2O溶液（目录号584223）提供。

应用


  • Oncotherapy resistance explained by Darwinian and Lamarckian models.: This research explores the mechanisms of oncotherapy resistance, combining Darwinian and Lamarckian models to provide a comprehensive understanding. The study highlights the role of Tetrahydrouridine in modulating therapy resistance pathways in cancer treatment (Saunthararajah et al., 2024).

  • Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy.: This study investigates the potential of using Tetrahydrouridine in non-cytotoxic therapies for small cell lung cancers, focusing on neuroendocrine lineage commitment and its implications for treatment efficacy (Biswas et al., 2023).

  • In Vitro Interaction of Tetrahydrouridine with Key Human Nucleoside Transporters.: This study explores how Tetrahydrouridine interacts with human nucleoside transporters, shedding light on its mechanisms of action and potential as a therapeutic agent in biochemistry and pharmacology (Säll et al., 2023).

  • Mycoplasma infection of cancer cells enhances anti-tumor effect of oxidized methylcytidines.: This research investigates how mycoplasma infection enhances the anti-tumor effects of oxidized methylcytidines, with Tetrahydrouridine playing a crucial role in the observed therapeutic outcomes (Pang et al., 2023).

包装

用惰性气体包装

警告

毒性：标准处理（A）

重悬

复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。贮备水溶液（中性或碱性pH值），在-20°C下可稳定保存长达3个月。

其他说明

Yusa, K., et al. 1995.Biochem.Biophys.Res. Commun.206, 486.
Bouffard, D.Y., et al. 1993.Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992.Cancer Chemotherap.Pharmacol.30, 7.
Riva, C., et al. 1992.Chemotherapy38, 358.
Yusa, K., et al. 1992.J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967.J. Am. Chem. Soc.89, 6720.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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