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Merck
CN
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文件

安全信息

580555

Sigma-Aldrich

Paclitaxel

from Taxus sp., ≥97% (HPLC), solid, antitumor agent, Calbiochem®

别名:

Paclitaxel, Taxus sp., Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL®

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About This Item

经验公式（希尔记法）:
C47H51NO14
CAS号:
33069-62-4
分子量:
853.91
MDL编号:
MFCD00869953
UNSPSC代码:
41116107
NACRES:
NA.77

product name

Paclitaxel, Taxus sp., Antitumor and antileukemic agent isolated from the bark of the yew tree.

质量水平

100

检测方案

≥97% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated
protect from light

颜色

white

溶解性

methanol: 1 mg/mL
DMSO: 10 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1

InChI key

RCINICONZNJXQF-VAZQATRQSA-N

一般描述

Antitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

生化/生理作用

Cell permeable: no
Primary Target
Promotes assembly of microtubules and inhibits tubulins disassembly
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol.35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci.97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Taxol is a registered trademark of Bristol-Myers Squibb Co.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H341,H360FD,H372

危险分类

Muta. 2 - Repr. 1B - STOT RE 1

靶器官

Central nervous system,Bone marrow,Cardio-vascular system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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