推荐产品
产品名称
(Z)-4-羟基-三苯氧胺，大包装, A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
质量水平
方案
≥99% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
methanol: 10 mg/mL
ethanol: 20 mg/mL (heating may be required)
运输
ambient
储存温度
2-8°C
InChI
1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChI key
DODQJNMQWMSYGS-QPLCGJKRSA-N
一般描述
生化/生理作用
主要靶标
PKC
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
警告
毒性：有害 & 致癌/致畸性（E）
重悬
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他说明
Gundimeda, U., et al. 1996.J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J.1996.Carcinogenesis 17, 1747.
Laser, R., et al. 1985.Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978.J. Toxicol.Environ.Health 4, 364.
Ye, Q. and Bodell, W.J.1996.Carcinogenesis 17, 1747.
Laser, R., et al. 1985.Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978.J. Toxicol.Environ.Health 4, 364.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
David Earl Hostallero et al.
Genomics, proteomics & bioinformatics, 21(3), 535-550 (2023-02-13)
Prediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely trained on preclinical cancer cell lines
Daniel R Schmidt et al.
Communications medicine, 3(1), 108-108 (2023-08-10)
Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality therapy used in patients. Radiation therapy (RT) is frequently used
Salli Antila et al.
Nature cardiovascular research, 3, 474-491 (2024-08-01)
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their possible involvement in Alzheimer's disease (AD). Here we find that
Kusmardi Kusmardi et al.
F1000Research, 10, 902-902 (2021-10-26)
Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE)
Si Chen et al.
Molecular carcinogenesis, 62(2), 249-260 (2022-11-03)
Breast cancer is the most common cancer in women worldwide. Although tamoxifen (TAM), a selective estrogen receptor (ER) modulator, is widely used to treat ER-positive breast cancers, resistance to TAM remains a major clinical problem. NADPH-dependent cytochrome P450 reductase (POR) is
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门