推荐产品
生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
TAU-5, monoclonal
表单
liquid
不包含
preservative
种属反应性
mouse, human, sheep, rat
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
同位素/亚型
IgG1
运输
wet ice
储存温度
−70°C
靶向翻译后修饰
unmodified
基因信息
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
一般描述
蛋白G纯化的小鼠单克隆抗体。识别约45-68 kDa磷酸化和非磷酸化形式的tau。
识别~45-68 kDa Tau蛋白。
该小鼠抗Tau mAb(TAU-5)经过验证，可用于冷冻切片、免疫印迹、免疫沉淀、石蜡切片以检测Tau。
免疫原
牛
纯化的牛微管相关蛋白
表位：中心区域内
应用
冷冻切片（1-2 µg/ml)
免疫印迹（1 µg/ml）
免疫沉淀（每200-500 µg细胞裂解液 10 µg）
石蜡切片（1-2 µg/ml，需要热预处理）
免疫印迹（1 µg/ml）
免疫沉淀（每200-500 µg细胞裂解液 10 µg）
石蜡切片（1-2 µg/ml，需要热预处理）
包装
特定浓度批号请参考小瓶的标签。
警告
毒性：标准处理（A）
外形
在PBS中。
重悬
初次解冻后，分装冻存（-70°C）。如果浓度为<50 µg/ml，请勿贮藏没有载体蛋白的稀释抗体。
其他说明
Papasozomenos, S.C. and Shanavas, A., 2002.Proc.Natl.Acad.Sci. USA99, 1140.
Rapoport, M., eta al.2002.Proc.Natl.Acad.Sci. USA99, 6364.
Rapoport, M., eta al.2002.Proc.Natl.Acad.Sci. USA99, 6364.
当用于福尔马林/石蜡包埋切片时，在10 mM枸橼酸盐缓冲液（pH 6.0）中煮沸组织切片10-20分钟，然后在抗体培养前在室温下冷却20分钟，从而增强染色。Tau mRNA的交替剪接和差异磷酸化促成tau的异质性。不与微管蛋白的其他MAPS发生交叉反应。识别天然和磷酸化形式的tau。合适的工作稀释度由与测定条件相关的变量决定。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ricardo Gargini et al.
Frontiers in aging neuroscience, 11, 231-231 (2019-09-26)
The analysis of global and comparative genomics between different diseases allows us to understand the key biological processes that explain the etiology of these pathologies. We have used this type of approach to evaluate the expression of several neurodegeneration-related genes
Michael Dumbacher et al.
Molecular neurodegeneration, 13(1), 50-50 (2018-09-28)
Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer's disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer's disease contributes to increased Ca2+ influx and aberrant neuronal activity, which accelerates neurodegeneration in a feed-forward fashion. As
Weijiang Dong et al.
Journal of neuroscience research, 87(14), 3176-3185 (2009-05-28)
Tau function is regulated by phosphorylation, and abnormal tau phosphorylation in neurons is one of the key processes associated with development of Alzheimer's disease and other tauopathies. In this study we provide evidence that phospholipid transfer protein (PLTP), one of
Ram Fridlich et al.
Molecular & cellular proteomics : MCP, 8(6), 1206-1218 (2009-03-13)
Rod-derived cone viability factor (RdCVF) is produced by the Nxnl1 gene that codes for a second polypeptide, RdCVFL, by alternative splicing. Although the role of RdCVF in promoting cone survival has been described, the implication of RdCVFL, a putative thioredoxin
Marta Fernández-Nogales et al.
Brain pathology (Zurich, Switzerland), 27(3), 314-322 (2016-06-25)
Increased incidence of neuronal nuclear indentations is a well-known feature of the striatum of Huntington's disease (HD) brains and, in Alzheimer's disease (AD), neuronal nuclear indentations have recently been reported to correlate with neurotoxicity caused by improper cytoskeletal/nucleoskeletal coupling. Initial
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门