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Merck
CN
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主要文件

574714

Sigma-Aldrich

BAY 61-3606

≥97% (HPLC), solid, Syk inhibitor, Calbiochem®

别名:

Syk Inhibitor IV, BAY 61-3606, 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

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About This Item

经验公式（希尔记法）:
C20H18N6O3 · xHCl · yH2O
CAS号:
732983-37-8
分子量:
390.40 (anhydrous free base basis)
MDL编号:
MFCD18641826
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

质量水平

100

方案

≥97% (HPLC)

表单

solid

效能

10 nM IC50

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

yellow

溶解性

DMSO: 10 mg/mL
water: 20 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[n]21c(ncc2)cc(nc1Nc4ncccc4C(=O)N)c3cc(c(cc3)OC)OC

InChI

1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)

InChI key

JWQOJVOKBAAAAR-UHFFFAOYSA-N

一般描述

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

生化/生理作用

Cell permeable: yes
Primary Target
Syk
Product competes with ATP.
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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