质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white to light orange
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC50 against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Xu, J., et al. 2008. J. Med. Chem.51, 4115.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Brian G Hunt et al.
Cancers, 14(10) (2022-05-29)
Aberrant RON signaling is present in numerous cancers including breast cancer. Evidence suggests that the ligand, hepatocyte growth factor-like (HGFL), is also overexpressed in breast cancer. RON (MST1R) and HGFL (MST1) genes are located on human chromosome 3 and mouse
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