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product name
STAT3抑制剂VI，S3I-201, STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, DNA-binding, & Stat3-dependent transcription.
质量水平
检测方案
≥95% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light beige
溶解性
DMSO: 10 mg/mL (Use only fresh, anhydrous DMSO.)
运输
ambient
储存温度
−20°C
InChI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key
HWNUSGNZBAISFM-UHFFFAOYSA-N
一般描述
一种细胞渗透性氨基水杨酸化合物，可结合Stat3-SH2结构域并阻止Stat3磷酸化/激活、二聚化、DNA结合和Stat3依赖性转录。显示在体外培养（有效浓度≤100 µM）和体内鼠异种移植模型（5 mg/kg，i.v.）中抑制Stat3依赖性肿瘤生长。也可以50 mM的DMSO溶液（目录号573130）提供。
包装
用惰性气体包装
警告
毒性：监管审查（Z）
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Wang, et al.
International Journal of Molecular Sciences, 24 (2023)
Kentaro Kajiwara et al.
Life science alliance, 4(4) (2021-02-13)
Compensatory growth of organs after loss of their mass and/or function is controlled by hepatocyte growth factor (HGF), but the underlying regulatory mechanisms remain elusive. Here, we show that CUB domain-containing protein 1 (CDCP1) promotes HGF-induced compensatory renal growth. Using
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