推荐产品
产品名称
STAT3抑制剂VI，S3I-201, STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, DNA-binding, & Stat3-dependent transcription.
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light beige
溶解性
DMSO: 10 mg/mL (Use only fresh, anhydrous DMSO.)
运输
ambient
储存温度
−20°C
一般描述
一种细胞渗透性氨基水杨酸化合物，可结合Stat3-SH2结构域并阻止Stat3磷酸化/激活、二聚化、DNA结合和Stat3依赖性转录。显示在体外培养（有效浓度≤100 µM）和体内鼠异种移植模型（5 mg/kg，i.v.）中抑制Stat3依赖性肿瘤生长。也可以50 mM的DMSO溶液（目录号573130）提供。
包装
用惰性气体包装
警告
毒性：监管审查（Z）
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Supriya Murthy et al.
Cell death & disease, 13(1), 53-53 (2022-01-14)
The danger signal extracellular calcium is pathophysiologically increased in the synovial fluid of patients with rheumatoid arthritis (RA). Calcium activates the NLRP3-inflammasome via the calcium-sensing receptor in monocytes/macrophages primed by lipopolysaccharide, and this effect is mediated by the uptake of
Mutation-Driven S100A8 Overexpression Confers Aberrant Phenotypes in Type 1 CALR-Mutated MPN.
Wang, et al.
International Journal of Molecular Sciences, 24 (2023)
Kentaro Kajiwara et al.
Life science alliance, 4(4) (2021-02-13)
Compensatory growth of organs after loss of their mass and/or function is controlled by hepatocyte growth factor (HGF), but the underlying regulatory mechanisms remain elusive. Here, we show that CUB domain-containing protein 1 (CDCP1) promotes HGF-induced compensatory renal growth. Using
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