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Merck
CN
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文件

573097

Sigma-Aldrich

STAT3抑制剂III，WP1066

STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.

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别名:
STAT3抑制剂III，WP1066
经验公式（希尔记法）:
C17H14BrN3O
CAS号:
857064-38-1
分子量:
356.22
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥97% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 10 mg/mL
ethanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

InChI key

VFUAJMPDXIRPKO-LQELWAHVSA-N

一般描述

一种细胞渗透性AG 490（目录号658401）酪磷蛋白类似物，在体外培养（使用U87-MG和U373-MG进行生存能力试验时，IC50分别为5.6和3.7 µM；在10 µM时对非肿瘤NHA无抑制作用）和小鼠体内培养中，作为有效的STAT3途径抑制剂和比AG 490更有效的抗肿瘤剂抑制恶性胶质瘤生长。显示在小鼠体内能跨越血脑屏障。也可提供InSolution格式（目录号573129）。
一种细胞渗透性AG 490（目录号658401）酪磷蛋白类似物，在体外培养（使用U87-MG和U373-MG进行生存能力试验时，IC50分别为5.6和3.7 µM；在10 µM时对非肿瘤NHA无抑制作用）和小鼠体内培养中，作为有效的STAT3途径抑制剂和比AG 490更有效的抗肿瘤剂抑制恶性胶质瘤生长。显示在小鼠体内能跨越血脑屏障。

生化/生理作用

主靶
STAT3通路
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：分别为5.6和3.7 µM，在使用U87-MG和U373-MG的活性试验中，抑制恶性胶质瘤生长

包装

用惰性气体包装

警告

毒性：刺激性（B）

重悬

复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。

其他说明

Iwamaru, A., et al. 2007.Oncogene,26, 2435.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Meng Chi et al.
Annals of translational medicine, 8(8), 531-531 (2020-05-16)
Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, has been reported to increase the malignancy of breast cancer cells in vitro and stimulate tumor growth in mice. Transmembrane protease serine 2 (TMPRSS2) demonstrates proteolytic activity, resulting in degradation of the
In-Hye Ham et al.
International journal of oncology, 61(1) (2022-05-28)
The present study aimed to investigate whether the Janus‑activated kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is a critical mechanism underlying the cancer‑associated fibroblast (CAF)‑induced chemoresistance of gastric cancer (GC). In addition, the present study tried to
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Cell death & disease, 13(4), 417-417 (2022-04-30)
Colorectal cancer (CRC) has a 5-year survival rate of <10%, as it can metastasize to the lungs and liver. Anticancer drugs and targeted therapies used to treat metastatic colorectal cancer have insufficient therapeutic efficacy and are associated with complications. Therefore
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Brain tumor stem cells (BTSCs) and intratumoral heterogeneity represent major challenges in glioblastoma therapy. Here, we report that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of BTSCs and glioblastoma resistance to therapy. Genetic deletion
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The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion/cation transporter
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