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Merck
CN
所有图片(1)

主要文件

572201

Millipore

链脲佐菌素

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

别名:

链脲佐菌素

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About This Item

经验公式(希尔记法):
C8H15N3O7
CAS号:
分子量:
265.22
MDL编号:
UNSPSC代码:
12352103

质量水平

方案

≥95% (HPLC)

表单

crystalline solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

off-white to pale yellow

溶解性

water: soluble

痕量阳离子

heavy metals: ≤5 ppm

运输

ambient

储存温度

−20°C

SMILES字符串

N(N=O)(C)C(=O)N[C@H]1[C@H](O[C@@H]([C@H]([C@@H]1O)O)CO)O

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

一般描述

含 N-亚硝基的促糖尿病化合物,在胰岛中充当一氧化氮供体。一种对革兰氏阴性细菌有效的抗生素。在胰腺胰岛细胞中引起 DNA 烷基化和 DNA 链断裂。
含 N-亚硝基的化合物,在胰岛中充当一氧化氮的供体。一种对革兰氏阴性细菌有效的抗生素。在胰腺胰岛细胞中引起 DNA 烷基化和 DNA 链断裂。致糖尿病剂。

警告

毒性:有害 & 致癌/致畸性(E)

重悬

溶液中不稳定;仅在使用前进行重悬。初次融化后,等分并冷冻(-20°C)。

其他说明

Kroncke, K.D., et al. 1995.Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994.FASEB J.8, 529.
Rasschaert, J., et al. 1992.Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E.1981.Cancer Res.41, 2786.
Adams, J., et al. 1981.Nature294, 284.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

FlameHealth hazard

警示用语:

Danger

危险声明

危险分类

Carc. 2 - Flam. Sol. 1 - Muta. 2

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high‑fat diet and streptozotocin‑induced type 2 diabetes mellitus (T2DM) mouse model.
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Molecular medicine reports, 23(2) (2020-12-15)
Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated the autophagy‑associated regulatory mechanisms of long non‑coding RNAs in cardiac pathological changes in diabetes mellitus (DM). Streptozotocin (STZ)‑induced

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