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Merck
CN

569397

Staurosporine

from Streptomyces sp., ≥99% (HPLC), solid, protein kinase inhibitor, Calbiochem

别名:

星形孢菌素链霉菌sp.

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关于此项目

经验公式（希尔记法）:
C28H26N4O3
化学文摘社编号:
62996-74-1
分子量:
466.53
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00077402

主要文件

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产品名称

星形孢菌素链霉菌sp., Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC50 = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).

SMILES string

[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C

InChI

1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

InChI key

HKSZLNNOFSGOKW-FYTWVXJKSA-N

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to pale yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

Quality Level

100

storage temp.

2-8°C

相关类别

Biochem/physiol Actions

产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
靶标IC50：针对蛋白激酶A、CaM激酶、肌球蛋白轻链激酶、蛋白激酶C和蛋白激酶G分别为7 nM、20 nM、1.3 nM、700 pM和8.5 nM。
首要靶标
PKA

Disclaimer

毒性：标准处理（A）

General description

一种有效的、细胞可渗透性、可逆性、ATP竞争性广谱蛋白激酶抑制剂。可抑制蛋白激酶A（IC50 = 7 nM）、CaM激酶（IC50 = 20 nM）、肌球蛋白轻链激酶（IC50 = 1.3 nM）、蛋白激酶C（IC50 = 700 pM）和蛋白激酶G（IC50 = 8.5 nM）。还可抑制胶原蛋白或ADP诱导的血小板凝集，但对凝血酶诱导的血小板凝集没有影响。诱导人恶性神经胶质瘤细胞系凋亡。在G1检查点对正常细胞进行阻滞。可提供1 mM 星形孢菌素（100 µg/214µl）（货号569396）的DMSO溶液。

Other Notes

Couldwell, W.T., et al. 1994.FEBS Lett.345, 43.
Nishimura, H. and Simpson, I.A.1994.生物化学。J. 302, 271.
Bruno, S., et al. 1992.Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992.生物化学。J. 288, 853.
Vitale, M.L., et al. 1992.Neuroscience51, 463.
Hoffman, R. and Newland, E.S.1991.Cancer Chemother.Pharmacol.28, 102.
Oka, S., et al. 1986.Agric. Biol. Chem.50, 2723.

Packaging

用惰性气体包装

Preparation Note

仅在使用前再用水相缓冲液进行稀释。
在重悬后分装并冻存于冰箱（-70°C）。储备液可在-70°C最长稳定6个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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