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569397

Sigma-Aldrich

Staurosporine

from Streptomyces sp., ≥99% (HPLC), solid, protein kinase inhibitor, Calbiochem

别名:

星形孢菌素链霉菌sp.

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About This Item

经验公式（希尔记法）:
C28H26N4O3
CAS号:
62996-74-1
分子量:
466.53
MDL编号:
MFCD00077402
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

星形孢菌素链霉菌sp., Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC₅₀ = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).

质量水平

100

方案

≥99% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white to pale yellow

溶解性

DMSO: 5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C

InChI

1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1

InChI key

HKSZLNNOFSGOKW-FYTWVXJKSA-N

一般描述

一种有效的、细胞可渗透性、可逆性、ATP竞争性广谱蛋白激酶抑制剂。可抑制CaM激酶（IC50 = 20 nM）、肌球蛋白轻链激酶（IC50 = 1.3 nM）、蛋白激酶A（IC50 = 7 nM）、蛋白激酶C（IC50 = 0.7 nM）和蛋白激酶G（IC50 = 8.5 nM）。还可抑制胶原蛋白或ADP诱导的血小板凝集，但对凝血酶诱导的血小板凝集没有影响。诱导人恶性神经胶质瘤细胞系凋亡。在G1检查点对正常细胞进行阻滞。
一种有效的、细胞可渗透性、可逆性、ATP竞争性广谱蛋白激酶抑制剂。可抑制蛋白激酶A（IC50 = 7 nM）、CaM激酶（IC50 = 20 nM）、肌球蛋白轻链激酶（IC50 = 1.3 nM）、蛋白激酶C（IC50 = 700 pM）和蛋白激酶G（IC50 = 8.5 nM）。还可抑制胶原蛋白或ADP诱导的血小板凝集，但对凝血酶诱导的血小板凝集没有影响。诱导人恶性神经胶质瘤细胞系凋亡。在G1检查点对正常细胞进行阻滞。可提供1 mM 星形孢菌素（100 µg/214µl）（货号569396）的DMSO溶液。

生化/生理作用

产物与ATP竞争。
可逆性：是
细胞可渗透性：具有
靶标IC50：针对蛋白激酶A、CaM激酶、肌球蛋白轻链激酶、蛋白激酶C和蛋白激酶G分别为7 nM、20 nM、1.3 nM、700 pM和8.5 nM。
首要靶标
PKA

包装

用惰性气体包装

警告

毒性：标准处理（A）

制备说明

仅在使用前再用水相缓冲液进行稀释。

重悬

在重悬后分装并冻存于冰箱（-70°C）。储备液可在-70°C最长稳定6个月。

其他说明

Couldwell, W.T., et al. 1994.FEBS Lett.345, 43.
Nishimura, H. and Simpson, I.A.1994.生物化学。J. 302, 271.
Bruno, S., et al. 1992.Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992.生物化学。J. 288, 853.
Vitale, M.L., et al. 1992.Neuroscience51, 463.
Hoffman, R. and Newland, E.S.1991.Cancer Chemother.Pharmacol.28, 102.
Oka, S., et al. 1986.Agric. Biol. Chem.50, 2723.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361d,H413

危险分类

Aquatic Chronic 4 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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