推荐产品
产品名称
星形孢菌素链霉菌sp., InSolution, ≥97%, 1 mM solution, protein kinase inhibitor
质量水平
方案
≥97% (HPLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
运输
wet ice
储存温度
−70°C
SMILES字符串
[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CNC7=O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C
InChI
1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChI key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
一般描述
一种有效的、细胞可渗透的广谱蛋白激酶抑制剂。可抑制CaM激酶（IC50 = 20 nM）、肌球蛋白轻链激酶（IC50 = 1.3 nM）、蛋白激酶A（IC50 = 7 nM）、蛋白激酶C（IC50 = 0.7 nM）和蛋白激酶G（IC50 = 8.5 nM）。还可抑制胶原蛋白或ADP诱导的血小板凝集，但对凝血酶诱导的血小板凝集没有影响。诱导人恶性神经胶质瘤细胞系凋亡。在G1检查点对正常细胞进行阻滞。
生化/生理作用
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：针对蛋白激酶A、CaM激酶、肌球蛋白轻链激酶、蛋白激酶C和蛋白激酶G分别为7 nM、20 nM、1.3 nM、700 pM和8.5 nM。
首要靶标
PKA
PKA
包装
用惰性气体包装
警告
毒性：刺激性（B）
外形
1 mM (100 µg/214 µl)星形孢菌素(目录号569397)的DMSO溶液。
重悬
初始解冻后，分装，用惰性气体吹扫，然后冻存（-70°C）。
其他说明
Couldwell, W.T., et al. 1994.FEBS Lett.345, 43.
Nishimura, H. and Simpson, I.A.1994.Biochem.J.302, 271.
Bruno, S., et al. 1992.Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992.Biochem.J.288, 853.
Vitale, M.L., et al. 1992.Neuroscience51, 463.
Hoffman, R. and Newland, E.S.1991.Cancer Chemotherap.Pharmacol.28, 102.
Oka, S., et al. 1986.Agric. Biol. Chem.50, 2723.
Nishimura, H. and Simpson, I.A.1994.Biochem.J.302, 271.
Bruno, S., et al. 1992.Cancer Res.52, 470.
Kiss, Z. and Deli, E. 1992.Biochem.J.288, 853.
Vitale, M.L., et al. 1992.Neuroscience51, 463.
Hoffman, R. and Newland, E.S.1991.Cancer Chemotherap.Pharmacol.28, 102.
Oka, S., et al. 1986.Agric. Biol. Chem.50, 2723.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
闪点(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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