所有图片(1)

文件

COA分析证书/COQ

567732

Sphingosine Kinase 1 Inhibitor, SKI-178

Name: Sphingosine Kinase 1 Inhibitor, SKI-178
Brand: MM

别名:

Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₁H₂₂N₄O₄

分子量:

394.42

UNSPSC代码:

12352200

NACRES:

NA.28

检测方案

≥92% (HPLC)

质量水平

100

形式

powder

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 100 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (K_i = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC₅₀ in the range of 0.1-1.8 µM).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.

Rui Sun et al.

Cell reports, 38(13), 110560-110560 (2022-03-31)

It is not clear how the complex interactions between diet and intestinal immune cells protect the gut from infection. Neutral ceramidase (NcDase) plays a critical role in digesting dietary sphingolipids. We find that NcDase is an essential factor that controls

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件